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Target
Glycogen debranching enzyme
Ligand
BDBM50259956
Substrate
n/a
Meas. Tech.
ChEMBL_490834 (CHEMBL993573)
IC50
110±n/a nM
Citation
 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem 16:7330-6 (2008) [PubMed]  Article 
Target
Name:
Glycogen debranching enzyme
Synonyms:
AGL | GDE_RABIT
Type:
PROTEIN
Mol. Mass.:
177662.68
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_490834
Residue:
1555
Sequence:
MGNSFDFGVLLILLKYFKSSRSQNGHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKPVTVFTNYPFPGETFNREKFRSLEWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYIVVDPILRVGADNHMLHLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLADQLELNPDFSRPHKKYTWSDVGQLVEKLKREWNVLCITDVVYNHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWHFSCDVAEGKYKNRGVPALIENDHHLNCIRKVIWEDIFPKLHLWEFFQVDVYKAVEKFRGLLTQETWRVIKSDPKQHLKIIQDPEYRRFGCTVDMNIALATFIPHDNGPAAIEECCNWFRKRIEELNSEKHQLMNYHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFTFPFEEMPVSTEETMIHLPNKACFFMAHNGWVMGDDPLRNFAEPGSDVYLRRELICWGDSVKLRYGTKPEDCPYLWAHMRKYTEIIATYFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAELFTGSEDLDNIFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSVYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFYTKWNPEALPSNAGEVNFQSGIIAARCAINKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQSFVAVSRTAFRNPKTSFYSKDVPQMCIPGKIEEVVLEARTIERNISPYRKDENSINGMPNITVEIREHIQLNESRIVKQAGVTTKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHLTQFSAHFKAGSLAVDNSDPILKIPFASIASKLTLAEINQILYRCESEEQEDGGGCYDIPNWSSLKYAGLQGLMSVLAEIRPKNDLGHPFCDNLRSGDWMIDYVSGRLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDIAWKQMSSFVQTGSTFVKHLSLGSVQMCGVGKFPSLPLLSPSLTDVPYRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWGRDTFIALRGLLLITGRYLEARNIILAFAGTLRHGLIPNLLGEGTYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFDVIQEAMQRHMQGIQFRERNAGPQIDRNMKDEGFTVIAGVNEETGFVYGGNRFNCGTWMDKMGESDRARNRGIPATPRDGSAVEIVGLCKSTVRWLLELSKKNIFPYHEVRVKRHGKVVTVSYEEWNRKIQDNFEKRFHVSEDPSASNEEHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPELFTAEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLAKGFNYHQGPEWLWPVGYFLRAKLYFSKLMDRETNARTIFLVKNVLSRHYVHLERSPWKGLPELTNENGQYCPFSCETQAWSIATILETLYDL
  
Inhibitor
Name:
BDBM50259956
Synonyms:
2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHEMBL501355 | US9181184, 34 | alpha-homonojirimycin
Type:
Small organic molecule
Emp. Form.:
C7H15NO5
Mol. Mass.:
193.1977
SMILES:
OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: