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Target
Neuronal acetylcholine receptor subunit alpha-3
Ligand
BDBM50263095
Substrate
n/a
Meas. Tech.
ChEMBL_489290 (CHEMBL990846)
Ki
0.13±n/a nM
Citation
 Gao, Y; Kuwabara, H; Spivak, CE; Xiao, Y; Kellar, K; Ravert, HT; Kumar, A; Alexander, M; Hilton, J; Wong, DF; Dannals, RF; Horti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem 51:4751-64 (2008) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-3
Synonyms:
ACHA3_RAT | Acra3 | Chrna3
Type:
Enzyme
Mol. Mass.:
56995.52
Organism:
Rattus norvegicus (Rat)
Description:
P04757
Residue:
499
Sequence:
MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT
  
Inhibitor
Name:
BDBM50263095
Synonyms:
(+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | CHEMBL514372
Type:
Small organic molecule
Emp. Form.:
C17H18FN3
Mol. Mass.:
283.3433
SMILES:
CN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1ccnc(F)c1 |r,TLB:8:6:3.4:1|
Structure:
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