Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-6
Ligand
BDBM50263130
Substrate
n/a
Meas. Tech.
ChEMBL_489293 (CHEMBL990849)
Ki
0.021±n/a nM
Citation
 Gao, Y; Kuwabara, H; Spivak, CE; Xiao, Y; Kellar, K; Ravert, HT; Kumar, A; Alexander, M; Hilton, J; Wong, DF; Dannals, RF; Horti, AG Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. J Med Chem 51:4751-64 (2008) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-6
Synonyms:
ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3
Type:
PROTEIN
Mol. Mass.:
56943.53
Organism:
Rattus norvegicus
Description:
ChEMBL_1454451
Residue:
493
Sequence:
MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS
  
Inhibitor
Name:
BDBM50263130
Synonyms:
(+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | (-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane | CHEMBL476140
Type:
Small organic molecule
Emp. Form.:
C17H18FN3
Mol. Mass.:
283.3433
SMILES:
CN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1cccnc1F |r,TLB:8:6:3.4:1|
Structure:
Search PDB for entries with ligand similarity: