Reaction Details Report a problem with these data
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Ligand
BDBM50275280
Substrate
n/a
Meas. Tech.
ChEMBL_496150 (CHEMBL1000139)
Ki
24±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms:
EBP | EBP_CAVPO
Type:
PROTEIN
Mol. Mass.:
26684.52
Organism:
Cavia porcellus
Description:
ChEMBL_203193
Residue:
229
Sequence:
MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLGTWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFIICMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEMGHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK
  
Inhibitor
Name:
BDBM50275280
Synonyms:
CHEMBL487359 | cis-4-(3-methoxyphenyl)-N-(2-(pyridin-2-yloxy)ethyl)cyclohexanamine
Type:
Small organic molecule
Emp. Form.:
C20H26N2O2
Mol. Mass.:
326.4326
SMILES:
COc1cccc(c1)[C@@H]1CC[C@@H](CC1)NCCOc1ccccn1 |r,wU:8.8,11.15,(8.88,4.05,;10.22,3.28,;11.55,4.05,;11.55,5.59,;12.88,6.36,;14.22,5.6,;14.22,4.04,;12.88,3.28,;15.56,3.28,;15.56,1.74,;16.88,.97,;18.22,1.74,;18.22,3.28,;16.89,4.05,;19.55,.96,;20.88,1.73,;22.22,.96,;23.55,1.72,;24.88,.95,;26.21,1.72,;27.54,.96,;27.54,-.59,;26.2,-1.36,;24.87,-.59,)|
Structure:
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