Reaction Details Report a problem with these data
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Ligand
BDBM50275321
Substrate
n/a
Meas. Tech.
ChEMBL_496150 (CHEMBL1000139)
Ki
45±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms:
EBP | EBP_CAVPO
Type:
PROTEIN
Mol. Mass.:
26684.52
Organism:
Cavia porcellus
Description:
ChEMBL_203193
Residue:
229
Sequence:
MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLGTWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFIICMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEMGHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK
  
Inhibitor
Name:
BDBM50275321
Synonyms:
CHEMBL521350 | cis-1-(4-(3-methoxyphenyl)cyclohexyl)-4-(pyridin-2-yl)piperazine
Type:
Small organic molecule
Emp. Form.:
C22H29N3O
Mol. Mass.:
351.4852
SMILES:
COc1cccc(c1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:8.8,11.15,(.19,-28.28,;1.52,-27.51,;1.52,-25.97,;.19,-25.2,;.19,-23.65,;1.52,-22.88,;2.85,-23.65,;2.86,-25.2,;4.18,-22.87,;5.52,-23.63,;6.85,-22.87,;6.85,-21.33,;5.51,-20.56,;4.17,-21.33,;8.17,-20.56,;9.51,-21.33,;10.84,-20.57,;10.84,-19.03,;9.51,-18.25,;8.17,-19.02,;12.18,-18.26,;12.18,-16.73,;13.51,-15.96,;14.85,-16.74,;14.84,-18.28,;13.51,-19.04,)|
Structure:
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