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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50107253
Substrate
n/a
Meas. Tech.
ChEMBL_496151 (CHEMBL1000140)
Ki
358±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50107253
Synonyms:
1-((6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)-4-(pyridin-2-yl)piperazine | 1-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-pyridin-2-yl-piperazine | CHEMBL138900
Type:
Small organic molecule
Emp. Form.:
C21H27N3O
Mol. Mass.:
337.4586
SMILES:
COc1ccc2CC(CN3CCN(CC3)c3ccccn3)CCc2c1
Structure:
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