Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50274836
Substrate
n/a
Meas. Tech.
ChEMBL_496151 (CHEMBL1000140)
Ki
291±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50274836
Synonyms:
CHEMBL458361 | trans-1-(4-(4-methoxyphenyl)cyclohexyl)-4-(pyridin-2-yl)piperazine
Type:
Small organic molecule
Emp. Form.:
C22H29N3O
Mol. Mass.:
351.4852
SMILES:
COc1ccc(cc1)[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:8.8,wD:11.15,(12.89,-36.27,;14.22,-37.04,;15.56,-36.27,;15.56,-34.73,;16.89,-33.96,;18.22,-34.72,;18.23,-36.27,;16.89,-37.04,;19.55,-33.94,;19.54,-32.41,;20.88,-31.63,;22.22,-32.4,;22.21,-33.94,;20.89,-34.71,;23.54,-31.63,;24.88,-32.41,;26.2,-31.64,;26.21,-30.1,;24.88,-29.33,;23.54,-30.1,;27.55,-29.34,;27.55,-27.81,;28.88,-27.04,;30.21,-27.81,;30.21,-29.35,;28.87,-30.12,)|
Structure:
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