Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50274839
Substrate
n/a
Meas. Tech.
ChEMBL_496151 (CHEMBL1000140)
Ki
1000±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50274839
Synonyms:
CHEMBL456435 | cis-4-[4-(2-Methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
Type:
Small organic molecule
Emp. Form.:
C22H29N3
Mol. Mass.:
335.4858
SMILES:
Cc1ccccc1[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:7.7,10.14,(14.09,-43.6,;14.1,-45.14,;12.77,-45.91,;12.77,-47.45,;14.1,-48.22,;15.44,-47.45,;15.43,-45.9,;16.76,-45.12,;18.09,-45.89,;19.42,-45.12,;19.42,-43.58,;18.09,-42.82,;16.75,-43.59,;20.75,-42.81,;22.08,-43.59,;23.41,-42.83,;23.42,-41.29,;22.09,-40.51,;20.75,-41.28,;24.75,-40.52,;24.75,-38.99,;26.08,-38.22,;27.42,-39,;27.41,-40.54,;26.08,-41.3,)|
Structure:
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