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Target
Isocitrate lyase
Ligand
BDBM50274515
Substrate
n/a
Meas. Tech.
ChEMBL_540910 (CHEMBL1026584)
IC50
50700±n/a nM
Citation
 Lee, HS; Yoon, KM; Han, YR; Lee, KJ; Chung, SC; Kim, TI; Lee, SH; Shin, J; Oh, KB 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp. Bioorg Med Chem Lett 19:1051-3 (2009) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_CANAX | ICL1
Type:
PROTEIN
Mol. Mass.:
61398.95
Organism:
Candida albicans
Description:
ChEMBL_972063
Residue:
550
Sequence:
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA
  
Inhibitor
Name:
BDBM50274515
Synonyms:
3-nitropropanoic acid | 3-nitropropionic acid | Bovinocidin | CHEMBL231421 | CHEMBL451226
Type:
Small organic molecule
Emp. Form.:
C3H4NO4
Mol. Mass.:
118.0687
SMILES:
[O-]C(=O)CC[N+]([O-])=O
Structure:
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