Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50122294
Substrate
n/a
Meas. Tech.
ChEMBL_563774 (CHEMBL993537)
Ki
0.08±n/a nM
Citation
 Yanamoto, K; Kumata, K; Yamasaki, T; Odawara, C; Kawamura, K; Yui, J; Hatori, A; Suzuki, K; Zhang, MR [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. Bioorg Med Chem Lett 19:1707-10 (2009) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50122294
Synonyms:
CHEMBL292092 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-(2-fluoroethoxy)-5-methoxybenzyl)acetamide | N-[2-(2-Fluoro-ethoxy)-5-methoxy-benzyl]-N-(5-fluoro-2-phenoxy-phenyl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C24H23F2NO4
Mol. Mass.:
427.4405
SMILES:
COc1ccc(OCCF)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: