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Target
Carbonic anhydrase 12
Ligand
BDBM11036
Substrate
n/a
Meas. Tech.
ChEMBL_544669 (CHEMBL1009246)
Ki
9±n/a nM
Citation
 Thiry, A; Rolin, S; Vullo, D; Frankart, A; Scozzafava, A; Dogné, JM; Wouters, J; Supuran, CT; Masereel, B Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem 43:2853-60 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM11036
Synonyms:
2-ethylamido-5-sulfonamidoindane | CHEMBL204740 | Indanesulfonamide Derivative 12d | N-(5-sulfamoyl-2,3-dihydro-1H-inden-2-yl)propanamide
Type:
Small organic molecule
Emp. Form.:
C12H16N2O3S
Mol. Mass.:
268.332
SMILES:
CCC(=O)NC1Cc2ccc(cc2C1)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: