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Target
Carbonic anhydrase 2
Ligand
BDBM50258733
Substrate
n/a
Meas. Tech.
ChEMBL_499839 (CHEMBL972471)
Ki
3820±n/a nM
Citation
 Gitto, R; Ferro, S; Agnello, S; De Luca, L; De Sarro, G; Russo, E; Vullo, D; Supuran, CT; Chimirri, A Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides. Bioorg Med Chem 17:3659-64 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50258733
Synonyms:
6,7-Dimethoxy-1-(3'-nitrophenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide | CHEMBL468105
Type:
Small organic molecule
Emp. Form.:
C17H19N3O6S
Mol. Mass.:
393.414
SMILES:
COc1cc2CCN(C(c3cccc(c3)[N+]([O-])=O)c2cc1OC)S(N)(=O)=O
Structure:
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