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Target
Sonic hedgehog protein
Ligand
BDBM50249185
Substrate
n/a
Meas. Tech.
ChEMBL_499790 (CHEMBL969584)
IC50
2.8±n/a nM
Citation
 Mahindroo, N; Punchihewa, C; Fujii, N Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 52:3829-45 (2009) [PubMed]  Article 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM50249185
Synonyms:
4-(4-cyclopropylquinazolin-2-ylamino)-N-(2,6-dimethylphenyl)benzamide | CHEMBL473191
Type:
Small organic molecule
Emp. Form.:
C26H24N4O
Mol. Mass.:
408.495
SMILES:
Cc1cccc(C)c1NC(=O)c1ccc(Nc2nc(C3CC3)c3ccccc3n2)cc1
Structure:
Search PDB for entries with ligand similarity: