Reaction Details Report a problem with these data
Target
Glutamate receptor ionotropic, kainate 2
Ligand
BDBM50126764
Substrate
n/a
Meas. Tech.
ChEMBL_573960 (CHEMBL1062121)
EC50
>1000000±n/a nM
Citation
 Clausen, RP; Naur, P; Kristensen, AS; Greenwood, JR; Strange, M; Bräuner-Osborne, H; Jensen, AA; Nielsen, AS; Geneser, U; Ringgaard, LM; Nielsen, B; Pickering, DS; Brehm, L; Gajhede, M; Krogsgaard-Larsen, P; Kastrup, JS The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. J Med Chem 52:4911-22 (2009) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 2
Synonyms:
GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5
Type:
PROTEIN
Mol. Mass.:
102478.61
Organism:
Rattus norvegicus
Description:
ChEMBL_936439
Residue:
908
Sequence:
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
  
Inhibitor
Name:
BDBM50126764
Synonyms:
(S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid | 2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)-propionic acid | 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE | CHEMBL28472
Type:
Small organic molecule
Emp. Form.:
C11H14N2O4
Mol. Mass.:
238.2399
SMILES:
N[C@@H](CC1=CCCCc2o[nH]c(=O)c12)C(O)=O |t:3|
Structure:
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