| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GRIA3 |
|---|
| Ligand | BDBM17657 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_573954 |
|---|
| EC50 | 52000±n/a nM |
|---|
| Citation |  Clausen, RP; Naur, P; Kristensen, AS; Greenwood, JR; Strange, M; Bräuner-Osborne, H; Jensen, AA; Nielsen, AS; Geneser, U; Ringgaard, LM; Nielsen, B; Pickering, DS; Brehm, L; Gajhede, M; Krogsgaard-Larsen, P; Kastrup, JS The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. J Med Chem52:4911-22 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GRIA3 |
|---|
| Name: | GRIA3 |
|---|
| Synonyms: | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 100383.57 |
|---|
| Organism: | RAT |
|---|
| Description: | Glutamate-AMPA GRIA3 RAT::P19492 |
|---|
| Residue: | 888 |
|---|
| Sequence: | MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNW
QVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLN
EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
|
|
|
|---|
| BDBM17657 |
|---|
| Name | BDBM17657 |
|---|
| Synonyms: | (2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate |
|---|
| Type | Amino Acid |
|---|
| Emp. Form. | C5H9NO4 |
|---|
| Mol. Mass. | 147.1293 |
|---|
| SMILES | N[C@@H](CCC(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
| n/a |
|---|
Search and Browse
