Reaction Details Report a problem with these data
Target
Glutathione S-transferase P
Ligand
BDBM50300265
Substrate
n/a
Meas. Tech.
ChEMBL_592934 (CHEMBL1049273)
IC50
3800±n/a nM
Citation
 Yang, X; Liu, G; Li, H; Zhang, Y; Song, D; Li, C; Wang, R; Liu, B; Liang, W; Jing, Y; Zhao, G Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation. J Med Chem 53:1015-22 (2010) [PubMed]  Article 
Target
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Inhibitor
Name:
BDBM50300265
Synonyms:
5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-methoxyphenyl)-1,2,4-oxadiazol | CHEMBL568727
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N2O4
Mol. Mass.:
433.285
SMILES:
CCC(=C)C(=O)c1ccc(OCc2nc(no2)-c2ccc(OC)cc2)c(Cl)c1Cl
Structure:
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