Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50378389
Substrate
n/a
Meas. Tech.
ChEMBL_588750 (CHEMBL1053697)
IC50
>100000±n/a nM
Citation
 Ma, X; Poon, TY; Wong, PT; Chui, WK Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett 19:5644-7 (2009) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM50378389
Synonyms:
CHEMBL583584 | GNF-PF-2559
Type:
Small organic molecule
Emp. Form.:
C12H17N5
Mol. Mass.:
231.2969
SMILES:
Cc1cccc(c1)N=C1NC(C)(C)NC(N)=N1 |w:7.7,c:16|
Structure:
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