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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301131
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
274±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301131
Synonyms:
(S)-5-guanidino-2-((R)-2-((S)-2-(3-(3-hydroxyphenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide | CHEMBL567240
Type:
Small organic molecule
Emp. Form.:
C30H37N9O5
Mol. Mass.:
603.6721
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1cccc(O)c1)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(33.78,-29.06,;32.45,-28.29,;32.46,-26.75,;31.12,-29.06,;29.78,-28.3,;28.45,-29.07,;27.11,-28.3,;27.11,-26.76,;25.78,-25.99,;24.45,-26.75,;24.45,-28.29,;23.12,-25.98,;23.12,-24.44,;21.78,-23.67,;21.78,-22.13,;20.45,-21.36,;19.12,-22.13,;19.12,-23.67,;20.45,-24.44,;21.78,-26.75,;21.79,-28.29,;23.13,-29.06,;20.46,-29.06,;19.12,-28.29,;17.79,-29.06,;16.39,-28.43,;15.36,-29.58,;16.13,-30.91,;17.63,-30.59,;20.45,-30.6,;21.79,-31.36,;23.12,-30.59,;21.79,-32.9,;20.45,-33.67,;20.45,-35.21,;19.11,-35.98,;19.11,-37.51,;20.45,-38.29,;21.78,-37.51,;23.12,-38.27,;21.78,-35.97,;28.45,-25.99,;29.78,-26.76,;28.45,-24.45,)|
Structure:
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