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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301134
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
1080±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301134
Synonyms:
(S)-2-((R)-2-((S)-2-(3-(4-chlorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL568577
Type:
Small organic molecule
Emp. Form.:
C30H36ClN9O4
Mol. Mass.:
622.118
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(Cl)cc1)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(35.53,-5.75,;34.19,-4.99,;34.2,-3.45,;32.85,-5.76,;31.51,-5,;30.19,-5.77,;28.85,-5,;28.85,-3.46,;27.52,-2.69,;26.19,-3.46,;26.19,-5,;24.86,-2.68,;24.86,-1.14,;23.52,-.38,;23.52,1.16,;22.19,1.94,;20.85,1.16,;20.85,-.38,;22.19,-1.14,;23.52,-3.45,;23.53,-4.99,;24.87,-5.76,;22.2,-5.76,;20.87,-4.99,;19.54,-5.76,;18.14,-5.13,;17.1,-6.28,;17.87,-7.61,;19.37,-7.29,;22.19,-7.3,;23.53,-8.06,;24.86,-7.29,;23.53,-9.6,;24.85,-10.37,;24.85,-11.9,;23.52,-12.66,;23.52,-14.19,;24.85,-14.96,;24.85,-16.49,;26.18,-14.18,;26.17,-12.65,;30.19,-2.69,;31.52,-3.46,;30.19,-1.15,)|
Structure:
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