Reaction Details Report a problem with these data
Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301150
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
1230±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301150
Synonyms:
(S)-2-((R)-2-((S)-2-(4-(4-fluorophenyl)-4-oxobutanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL568836
Type:
Small organic molecule
Emp. Form.:
C31H38FN9O5
Mol. Mass.:
635.6891
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(11.74,-24.83,;10.41,-24.06,;10.42,-22.52,;9.07,-24.83,;7.73,-24.07,;6.41,-24.84,;5.07,-24.07,;5.07,-22.53,;3.74,-21.76,;2.4,-22.53,;2.4,-24.07,;1.08,-21.76,;1.08,-20.22,;-.26,-19.45,;-.26,-17.91,;-1.59,-17.14,;-2.92,-17.91,;-2.92,-19.45,;-1.59,-20.22,;-.26,-22.53,;-.25,-24.07,;1.09,-24.83,;-1.58,-24.83,;-2.91,-24.07,;-4.24,-24.83,;-5.65,-24.2,;-6.68,-25.36,;-5.91,-26.69,;-4.4,-26.36,;-1.59,-26.37,;-.25,-27.13,;1.08,-26.36,;-.25,-28.67,;-1.59,-29.44,;-1.59,-30.98,;-.25,-31.75,;-2.92,-31.75,;-4.25,-30.97,;-5.58,-31.75,;-5.58,-33.29,;-6.92,-34.06,;-4.24,-34.05,;-2.91,-33.28,;6.41,-21.76,;7.73,-22.53,;6.41,-20.22,)|
Structure:
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