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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301152
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
780±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301152
Synonyms:
CHEMBL568965 | N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamide
Type:
Small organic molecule
Emp. Form.:
C33H39N9O6
Mol. Mass.:
657.7195
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=CC=Cc1ccc2OCOc2c1)C(N)=O |r,w:32.33,34.35,wU:22.30,7.7,wD:11.19,(19.61,-41.63,;18.27,-40.87,;18.28,-39.33,;16.93,-41.64,;15.59,-40.88,;14.27,-41.65,;12.93,-40.88,;12.93,-39.34,;11.6,-38.57,;10.27,-39.34,;10.27,-40.88,;8.94,-38.56,;8.94,-37.02,;7.6,-36.25,;7.6,-34.71,;6.27,-33.94,;4.93,-34.71,;4.93,-36.25,;6.27,-37.02,;7.6,-39.33,;7.61,-40.87,;8.95,-41.64,;6.28,-41.64,;4.95,-40.87,;3.62,-41.64,;2.22,-41.01,;1.18,-42.16,;1.95,-43.49,;3.45,-43.17,;6.27,-43.18,;7.61,-43.94,;8.94,-43.17,;7.61,-45.48,;6.27,-46.25,;6.27,-47.79,;4.94,-48.56,;4.94,-50.09,;6.27,-50.84,;6.28,-52.37,;4.95,-53.15,;4.64,-54.65,;3.11,-54.81,;2.49,-53.41,;3.62,-52.38,;3.63,-50.86,;14.27,-38.57,;15.6,-39.34,;14.27,-37.03,)|
Structure:
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