Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50301127
Substrate
n/a
Meas. Tech.
ChEMBL_598566 (CHEMBL1043558)
EC50
12850±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36966.58
Organism:
Mus musculus (Mouse)
Description:
P41149
Residue:
325
Sequence:
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
  
Inhibitor
Name:
BDBM50301127
Synonyms:
(S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(2-methoxyphenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL566545
Type:
Small organic molecule
Emp. Form.:
C31H39N9O5
Mol. Mass.:
617.6987
SMILES:
COc1ccccc1C=CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(N)=O |r,w:9.10,wU:13.13,34.36,wD:23.24,(7.6,-51.86,;6.26,-51.1,;4.93,-51.87,;4.94,-53.41,;3.6,-54.19,;2.26,-53.41,;2.26,-51.87,;3.6,-51.12,;3.6,-49.58,;4.94,-48.8,;4.94,-47.26,;6.27,-46.5,;3.6,-46.51,;3.61,-44.97,;2.27,-44.2,;.94,-44.97,;-.46,-44.34,;-1.49,-45.49,;-.73,-46.82,;.78,-46.5,;4.94,-44.2,;6.28,-44.97,;4.93,-42.66,;6.26,-41.89,;6.26,-40.35,;4.93,-39.58,;4.93,-38.04,;3.6,-37.27,;2.26,-38.04,;2.26,-39.58,;3.6,-40.35,;7.59,-42.66,;7.59,-44.2,;8.93,-41.89,;10.26,-42.67,;10.26,-44.21,;11.6,-44.97,;12.92,-44.21,;14.26,-44.96,;15.6,-44.2,;16.94,-44.95,;15.61,-42.65,;11.6,-41.89,;12.92,-42.67,;11.6,-40.35,)|
Structure:
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