Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50301142
Substrate
n/a
Meas. Tech.
ChEMBL_598566 (CHEMBL1043558)
EC50
17600±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36966.58
Organism:
Mus musculus (Mouse)
Description:
P41149
Residue:
325
Sequence:
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
  
Inhibitor
Name:
BDBM50301142
Synonyms:
(R)-2-((R)-2-((S)-2-(3-(2,4-difluorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL569076
Type:
Small organic molecule
Emp. Form.:
C30H35F2N9O4
Mol. Mass.:
623.6536
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(F)cc1F)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(33.25,-4.16,;31.92,-3.39,;31.93,-1.84,;30.59,-4.16,;29.25,-3.39,;27.93,-4.17,;26.59,-3.39,;26.59,-1.85,;25.26,-1.08,;23.92,-1.85,;23.92,-3.39,;22.59,-1.08,;22.59,.46,;21.25,1.23,;21.25,2.77,;19.92,3.54,;18.59,2.77,;18.59,1.23,;19.92,.46,;21.25,-1.85,;21.26,-3.39,;22.6,-4.16,;19.93,-4.16,;18.59,-3.39,;17.26,-4.16,;15.86,-3.53,;14.83,-4.68,;15.59,-6.01,;17.1,-5.69,;19.92,-5.7,;21.26,-6.46,;22.59,-5.69,;21.26,-8,;19.92,-8.77,;19.92,-10.31,;18.58,-11.07,;18.58,-12.61,;19.92,-13.39,;19.92,-14.93,;21.26,-12.6,;21.25,-11.07,;22.58,-10.3,;27.93,-1.09,;29.25,-1.85,;27.93,.45,)|
Structure:
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