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Target
Transcription factor HES-1
Ligand
BDBM50378457
Substrate
n/a
Meas. Tech.
ChEMBL_598858 (CHEMBL1044690)
IC50
7800±n/a nM
Citation
 Arai, MA; Masada, A; Ohtsuka, T; Kageyama, R; Ishibashi, M The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett 19:5778-81 (2009) [PubMed]  Article 
Target
Name:
Transcription factor HES-1
Synonyms:
HES1_MOUSE | Hairy and enhancer of split 1 | Hes-1 | Hes1
Type:
PROTEIN
Mol. Mass.:
29762.25
Organism:
Mus musculus
Description:
ChEMBL_598858
Residue:
282
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
  
Inhibitor
Name:
BDBM50378457
Synonyms:
CHEMBL572017
Type:
Small organic molecule
Emp. Form.:
C24H28O13
Mol. Mass.:
524.4713
SMILES:
C\C=C1\[C@H]2OC=C([C@H]1CC(=O)OC[C@@H](OC[C@H]1O[C@@H](O2)[C@H](O)[C@@H](O)[C@@H]1O)c1ccc(O)c(O)c1)C(O)=O |r,c:5|
Structure:
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