Reaction Details Report a problem with these data
Target
Transcription factor HES-1
Ligand
BDBM50378458
Substrate
n/a
Meas. Tech.
ChEMBL_598858 (CHEMBL1044690)
IC50
48100±n/a nM
Citation
 Arai, MA; Masada, A; Ohtsuka, T; Kageyama, R; Ishibashi, M The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett 19:5778-81 (2009) [PubMed]  Article 
Target
Name:
Transcription factor HES-1
Synonyms:
HES1_MOUSE | Hairy and enhancer of split 1 | Hes-1 | Hes1
Type:
PROTEIN
Mol. Mass.:
29762.25
Organism:
Mus musculus
Description:
ChEMBL_598858
Residue:
282
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
  
Inhibitor
Name:
BDBM50378458
Synonyms:
LYONISIDE
Type:
Small organic molecule
Emp. Form.:
C27H36O12
Mol. Mass.:
552.5675
SMILES:
COc1cc2C[C@@H](CO)[C@H](CO[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@@H](c3cc(OC)c(O)c(OC)c3)c2c(OC)c1O |r|
Structure:
Search PDB for entries with ligand similarity: