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Target
Sodium/glucose cotransporter 2
Ligand
BDBM50302607
Substrate
n/a
Meas. Tech.
ChEMBL_594779 (CHEMBL1040740)
IC50
2200±n/a nM
Citation
 Goodwin, NC; Mabon, R; Harrison, BA; Shadoan, MK; Almstead, ZY; Xie, Y; Healy, J; Buhring, LM; DaCosta, CM; Bardenhagen, J; Mseeh, F; Liu, Q; Nouraldeen, A; Wilson, AG; Kimball, SD; Powell, DR; Rawlins, DB Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem 52:6201-4 (2009) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SC5A2_MOUSE | Sglt2 | Slc5a2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2 | sodium-dependent glucose cotransporter 2 (SGLT2)
Type:
Protein
Mol. Mass.:
73014.31
Organism:
Mus musculus (Mouse)
Description:
Q923I7
Residue:
670
Sequence:
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA
  
Inhibitor
Name:
BDBM50302607
Synonyms:
(2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(2-(dimethylamino)ethoxy)tetrahydro-2H-pyran-3,4,5-triol | CHEMBL567954
Type:
Small organic molecule
Emp. Form.:
C24H32ClNO6
Mol. Mass.:
465.967
SMILES:
CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OCCN(C)C)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: