Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50303005
Substrate
n/a
Meas. Tech.
ChEMBL_596785 (CHEMBL1041807)
IC50
2700±n/a nM
Citation
 Hoang, DMNgoc, TMDat, NTHa, do TKim, YHLuong, HVAhn, JSBae, K Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett 19:6759-61 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50303005
Synonyms:
CHEMBL570475 | kuwanon J
Type:
Small organic molecule
Emp. Form.:
C40H38O10
Mol. Mass.:
678.7237
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(cc1-[#8])-[#6](=O)-[#6@@H]-1-[#6@H](-[#6]-[#6](-[#6])=[#6]-[#6@@H]-1-c1c(-[#8])ccc(-[#6](=O)-[#6]=[#6]-c2ccc(-[#8])cc2-[#8])c1-[#8])-c1ccc(-[#8])cc1-[#8] |r,w:30.31,c:20|
Structure:
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