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Target
NAD-dependent protein deacetylase HST2
Ligand
BDBM50304354
Substrate
n/a
Meas. Tech.
ChEMBL_606799 (CHEMBL1067344)
IC50
19900±n/a nM
Citation
 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem 17:7031-41 (2009) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase HST2
Synonyms:
HST2 | HST2_YEAST | NAD-dependent deacetylase HST2
Type:
PROTEIN
Mol. Mass.:
39972.79
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_533704
Residue:
357
Sequence:
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
  
Inhibitor
Name:
BDBM50304354
Synonyms:
3-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid | 3-(1-oxoisoindolin-2-yl)propanoic acid | CHEMBL82949 | cid_648461
Type:
Small organic molecule
Emp. Form.:
C11H11NO3
Mol. Mass.:
205.2099
SMILES:
OC(=O)CCN1Cc2ccccc2C1=O
Structure:
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