Reaction Details Report a problem with these data
Target
Asialoglycoprotein receptor 1
Ligand
BDBM50304486
Substrate
n/a
Meas. Tech.
ChEMBL_603824 (CHEMBL1042964)
IC50
113000±n/a nM
Citation
 Stokmaier, D; Khorev, O; Cutting, B; Born, R; Ricklin, D; Ernst, TO; Böni, F; Schwingruber, K; Gentner, M; Wittwer, M; Spreafico, M; Vedani, A; Rabbani, S; Schwardt, O; Ernst, B Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorg Med Chem 17:7254-64 (2009) [PubMed]  Article 
Target
Name:
Asialoglycoprotein receptor 1
Synonyms:
ASGP-R 1 | ASGPR 1 | ASGR1 | ASGR1_HUMAN | CLEC4H1 | Hepatic lectin H1
Type:
PROTEIN
Mol. Mass.:
33177.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_603824
Residue:
291
Sequence:
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
  
Inhibitor
Name:
BDBM50304486
Synonyms:
(3R,4R,5R,6R)-3-acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate | CHEMBL610736
Type:
Small organic molecule
Emp. Form.:
C16H23NO10
Mol. Mass.:
389.3545
SMILES:
CC(=O)N[C@H]1C(OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O |r|
Structure:
Search PDB for entries with ligand similarity: