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Target
Myelin-associated glycoprotein
Ligand
BDBM50327098
Substrate
n/a
Meas. Tech.
ChEMBL_611885 (CHEMBL1070840)
Kd
17800±n/a nM
Citation
 Mesch, S; Moser, D; Strasser, DS; Kelm, A; Cutting, B; Rossato, G; Vedani, A; Koliwer-Brandl, H; Wittwer, M; Rabbani, S; Schwardt, O; Kelm, S; Ernst, B Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation. J Med Chem 53:1597-615 (2010) [PubMed]  Article 
Target
Name:
Myelin-associated glycoprotein
Synonyms:
MAG_MOUSE | Mag | Siglec-4a
Type:
PROTEIN
Mol. Mass.:
69368.91
Organism:
Mus musculus
Description:
ChEMBL_663794
Residue:
627
Sequence:
MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50327098
Synonyms:
CHEMBL1254099 | sodium(2R,4S,5R,6R)-5-acetamido-6-((1R,2R)-3-benzamido-1,2-dihydroxypropyl)-2-(benzyloxy)-4-hydroxytetrahydro-2H-pyran-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H29N2O9
Mol. Mass.:
501.5063
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C[C@@](OCc2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNC(=O)c1ccccc1)C([O-])=O |r|
Structure:
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