Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50307344
Substrate
n/a
Meas. Tech.
ChEMBL_610634 (CHEMBL1069648)
Ki
7900±n/a nM
Citation
 Wang, S; Beck, R; Blench, T; Burd, A; Buxton, S; Malic, M; Ayele, T; Shaikh, S; Chahwala, S; Chander, C; Holland, R; Merette, S; Zhao, L; Blackney, M; Watts, A Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem 53:1465-72 (2010) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50307344
Synonyms:
6-(4-Methyl-benzyloxy)-benzo[b]thiophene-2-carboxamidine | CHEMBL609324
Type:
Small organic molecule
Emp. Form.:
C23H20N2OS
Mol. Mass.:
372.483
SMILES:
Cc1ccc(COc2cccc(c2)-c2ccc3sc(cc3c2)C(N)=N)cc1
Structure:
Search PDB for entries with ligand similarity: