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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50378636
Substrate
n/a
Meas. Tech.
ChEMBL_610636 (CHEMBL1069650)
IC50
252±n/a nM
Citation
 Wu, Y; Tai, HH; Cho, H Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorg Med Chem 18:1428-33 (2010) [PubMed]  Article 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50378636
Synonyms:
CHEMBL607870 | US8637558, 29
Type:
Small organic molecule
Emp. Form.:
C18H13NO5S
Mol. Mass.:
355.365
SMILES:
OC1=NC(=O)C(S1)=Cc1ccc(OCc2ccc3OCOc3c2)cc1 |w:7.8,t:1|
Structure:
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