Reaction Details Report a problem with these data
Target
Glutamate receptor 2
Ligand
BDBM50318264
Substrate
n/a
Meas. Tech.
ChEMBL_629329 (CHEMBL1104009)
Ki
43.0±n/a nM
Citation
 Lolli, ML; Giordano, C; Pickering, DS; Rolando, B; Hansen, KB; Foti, A; Contreras-Sanz, A; Amir, A; Fruttero, R; Gasco, A; Nielsen, B; Johansen, TN 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. J Med Chem 53:4110-8 (2010) [PubMed]  Article 
Target
Name:
Glutamate receptor 2
Synonyms:
GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2
Type:
PROTEIN
Mol. Mass.:
98691.74
Organism:
Rattus norvegicus
Description:
ChEMBL_936441
Residue:
883
Sequence:
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
  
Inhibitor
Name:
BDBM50318264
Synonyms:
(+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)propionicAcid
Type:
Small organic molecule
Emp. Form.:
C5H7N3O4
Mol. Mass.:
173.1268
SMILES:
NC(Cc1no[nH]c1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: