Target
Lysosomal acid lipase/cholesteryl ester hydrolase
Ligand
BDBM50318693
Substrate
n/a
Meas. Tech.
ChEMBL_633497 (CHEMBL1119694)
IC50
496±n/a nM
Citation
 Rosenbaum, AICosner, CCMariani, CJMaxfield, FRWiest, OHelquist, P Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem 53:5281-9 (2010) [PubMed]  Article 
Target
Name:
Lysosomal acid lipase/cholesteryl ester hydrolase
Synonyms:
LICH_HUMAN | LIPA
Type:
PROTEIN
Mol. Mass.:
45422.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_633497
Residue:
399
Sequence:
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
  
Inhibitor
Name:
BDBM50318693
Synonyms:
4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl Piperidine-1-carboxylate | CHEMBL1085855
Type:
Small organic molecule
Emp. Form.:
C12H18N4O2S
Mol. Mass.:
282.362
SMILES:
O=C(Oc1nsnc1N1CCCC1)N1CCCCC1
Structure:
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