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Target
Carbonic anhydrase 2
Ligand
BDBM50320031
Substrate
n/a
Meas. Tech.
ChEMBL_635089 (CHEMBL1119399)
Ki
28±n/a nM
Citation
 Esteves, MA; Ortet, O; Capelo, A; Supuran, CT; Marques, SM; Santos, MA New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors. Bioorg Med Chem Lett 20:3623-7 (2010) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50320031
Synonyms:
4-{3-[2-(4-sulfamoyl-phenyl)-ethyl-carbamoyl]propylamino}-1-hydroxy-2(1H)-pyrimidinone | CHEMBL1085555
Type:
Small organic molecule
Emp. Form.:
C16H21N5O5S
Mol. Mass.:
395.433
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)CCCNc2ccn(O)c(=O)n2)cc1
Structure:
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