Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50321533
Substrate
n/a
Meas. Tech.
ChEMBL_639627 (CHEMBL1175305)
IC50
8±n/a nM
Citation
 Cheung, AW; Brinkman, J; Firooznia, F; Flohr, A; Grimsby, J; Gubler, ML; Guertin, K; Hamid, R; Marcopulos, N; Norcross, RD; Qi, L; Ramsey, G; Tan, J; Wen, Y; Sarabu, R 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists. Bioorg Med Chem Lett 20:4140-6 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50321533
Synonyms:
CHEMBL1171525 | methyl 2-(N-(2-(4-fluorobenzamido)-4-methoxybenzo[d]thiazol-7-yl)acetamido)acetate
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O5S
Mol. Mass.:
431.437
SMILES:
COC(=O)CN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12
Structure:
Search PDB for entries with ligand similarity: