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Target
DNA polymerase I, thermostable
Ligand
BDBM50321612
Substrate
n/a
Meas. Tech.
ChEMBL_639807 (CHEMBL1175752)
IC50
53200±n/a nM
Citation
 Liu, XH; Liu, HF; Shen, X; Song, BA; Bhadury, PS; Zhu, HL; Liu, JX; Qi, XB Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. Bioorg Med Chem Lett 20:4163-7 (2010) [PubMed]  Article 
Target
Name:
DNA polymerase I, thermostable
Synonyms:
DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA
Type:
PROTEIN
Mol. Mass.:
93906.95
Organism:
Thermus aquaticus
Description:
ChEMBL_1289218
Residue:
832
Sequence:
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
  
Inhibitor
Name:
BDBM50321612
Synonyms:
1-(5-(2-((6-Chloropyridin-3-yl)methoxy)phenyl)-3-methyl-4,5-dihydropyrazol-1-yl) | CHEMBL1171529
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O2
Mol. Mass.:
343.807
SMILES:
CC(=O)N1N=C(C)CC1c1ccccc1OCc1ccc(Cl)nc1 |t:4|
Structure:
Search PDB for entries with ligand similarity: