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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50321672
Substrate
n/a
Meas. Tech.
ChEMBL_639904 (CHEMBL1173978)
IC50
>100000±n/a nM
Citation
 Matthews, TP; McHardy, T; Klair, S; Boxall, K; Fisher, M; Cherry, M; Allen, CE; Addison, GJ; Ellard, J; Aherne, GW; Westwood, IM; van Montfort, R; Garrett, MD; Reader, JC; Collins, I Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett 20:4045-9 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50321672
Synonyms:
3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline | CHEMBL1169926
Type:
Small organic molecule
Emp. Form.:
C15H12N6
Mol. Mass.:
276.296
SMILES:
Nc1cccc(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1
Structure:
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