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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50322036
Substrate
n/a
Meas. Tech.
ChEMBL_642463 (CHEMBL1175836)
IC50
1±n/a nM
Citation
 Tsukada, T; Kanno, O; Yamane, T; Tanaka, J; Yoshida, T; Okuno, A; Shiiki, T; Takahashi, M; Nishi, T Discovery of potent and orally active tricyclic-based FBPase inhibitors. Bioorg Med Chem 18:5346-51 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50322036
Synonyms:
CHEMBL1173125 | Ethyl(2S,6S)-4-{[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate4-oxide
Type:
Small organic molecule
Emp. Form.:
C22H29N4O7PS
Mol. Mass.:
524.527
SMILES:
CCOC(=O)[C@H](C)NP(=O)(COc1ccc(C(N)=O)c2Cc3scnc3-c12)N[C@@H](C)C(=O)OCC |r|
Structure:
Search PDB for entries with ligand similarity: