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Target
KiSS-1 receptor
Ligand
BDBM50322299
Substrate
n/a
Meas. Tech.
ChEMBL_642625 (CHEMBL1176768)
IC50
15±n/a nM
Citation
 Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Nakayama, M; Kiba, A; Kusaka, M; Matsumoto, S; Yamaguchi, M; Itoh, F; Baba, A 2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats. Bioorg Med Chem 18:5157-71 (2010) [PubMed]  Article 
Target
Name:
KiSS-1 receptor
Synonyms:
Gpr54 | KISSR_RAT | Kiss1r
Type:
PROTEIN
Mol. Mass.:
42915.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1448383
Residue:
396
Sequence:
MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVRRSPSVQDEHTAPL
  
Inhibitor
Name:
BDBM50322299
Synonyms:
CHEMBL1173643 | N-[3-Cyano-6-(4-fluoro-2-hydroxyphenyl)-4-(3-piperazin-1-ylphenyl)pyridin-2-yl]furan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C27H22FN5O3
Mol. Mass.:
483.4937
SMILES:
Oc1cc(F)ccc1-c1cc(-c2cccc(c2)N2CCNCC2)c(C#N)c(NC(=O)c2ccco2)n1
Structure:
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