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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50322695
Substrate
n/a
Meas. Tech.
ChEMBL_642072 (CHEMBL1176104)
EC50
158±n/a nM
Citation
 Seto, S; Okada, K; Kiyota, K; Isogai, S; Iwago, M; Shinozaki, T; Kitamura, Y; Kohno, Y; Murakami, K Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone. J Med Chem 53:5012-24 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | PPARG_RAT | Pparg
Type:
PROTEIN
Mol. Mass.:
57562.54
Organism:
Rattus norvegicus
Description:
ChEMBL_642067
Residue:
505
Sequence:
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50322695
Synonyms:
4,6-Bis(benzylthio)-2-(methylthio)pyrimidine-5-carboxylic Acid | CHEMBL1172425
Type:
Small organic molecule
Emp. Form.:
C20H18N2O2S3
Mol. Mass.:
414.564
SMILES:
CSc1nc(SCc2ccccc2)c(C(O)=O)c(SCc2ccccc2)n1
Structure:
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