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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50323672
Substrate/Competitorn/a
Meas. Tech.ChEMBL_645075
Ki 1580±n/a nM
Citation Lowe, JADeNinno, SLCoe, JWZhang, LMente, SHurst, RSMather, RJWard, KMShrikhande, ARollema, HJohnson, DEHorner, WGorczyca, RTingley, FDKozak, RMajchrzak, MJTritto, TSadlier, JShaffer, CLEllerbrock, BOsgood, SMMacDougall, MCMcDowell, LL A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists. Bioorg Med Chem Lett20:4749-52 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:n/a
Mol. Mass.:56448.33
Organism:Homo sapiens (Human)
Description: CHRNA7 (NACHRA7)
Residue:502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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  Blast E-value cutoff:
BDBM50323672
NameBDBM50323672
Synonyms:(1R,6S,5R)-[6-(2-(5-Hydroxypyridin-3-yl)phenoxy))]-3-azabicyclo[3.2.1]octane hydrochloride | CHEMBL1209124 | rac-exo-[6-(2-(5-Hydroxypyridin-3-yl)phenoxy))]-3-azabicyclo[3.2.1]octane
TypeSmall organic molecule
Emp. Form.C18H20N2O2
Mol. Mass.296.3636
SMILESOc1cncc(c1)-c1ccccc1O[C@H]1C[C@H]2C[C@@H]1CNC2 |r|
Structure
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n/a