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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50166908
Substrate
n/a
Meas. Tech.
ChEMBL_645075 (CHEMBL1211581)
Ki
125±n/a nM
Citation
 Lowe, JA; DeNinno, SL; Coe, JW; Zhang, L; Mente, S; Hurst, RS; Mather, RJ; Ward, KM; Shrikhande, A; Rollema, H; Johnson, DE; Horner, W; Gorczyca, R; Tingley, FD; Kozak, R; Majchrzak, MJ; Tritto, T; Sadlier, J; Shaffer, CL; Ellerbrock, B; Osgood, SM; MacDougall, MC; McDowell, LL A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists. Bioorg Med Chem Lett 20:4749-52 (2010) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50166908
Synonyms:
5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride | CHEMBL556954 | US9993465, Varenicline | VARENICLINE
Type:
Small organic molecule
Emp. Form.:
C13H13N3
Mol. Mass.:
211.2624
SMILES:
C1C2CNCC1c1cc3nccnc3cc21
Structure:
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