Target
Macrophage migration inhibitory factor
Ligand
BDBM50326576
Substrate
n/a
Meas. Tech.
ChEMBL_661807 (CHEMBL1252123)
IC50
57500±n/a nM
Citation
 El Turk, FFauvet, BOuertatani-Sakouhi, HLugari, ABetzi, SRoche, PMorelli, XLashuel, HA An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 18:5425-40 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50326576
Synonyms:
3-(2,4-difluorophenylamino)-1-(5-methylfuran-2-yl)prop-2-en-1-one | CHEMBL1253546
Type:
Small organic molecule
Emp. Form.:
C14H11F2NO2
Mol. Mass.:
263.2394
SMILES:
Cc1ccc(o1)C(=O)CC=Nc1ccc(F)cc1F |w:9.9|
Structure:
Search PDB for entries with ligand similarity: