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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50335013
Substrate
n/a
Meas. Tech.
ChEMBL_702705 (CHEMBL1657779)
IC50
920±n/a nM
Citation
 Kohara, A; Doihara, H; Saita, K; Aota, M Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors. J Med Chem 54:387-91 (2011) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
71066.17
Organism:
attus norvegicus (Rat)
Description:
Glycine-1-transporter 0 HUMAN::P28572
Residue:
638
Sequence:
MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50335013
Synonyms:
3-Biphenyl-4-yl-4-(2-ethylphenyl)-5-methyl-4H-1,2,4-triazole | CHEMBL1649959
Type:
Small organic molecule
Emp. Form.:
C23H21N3
Mol. Mass.:
339.4329
SMILES:
CCc1ccccc1-n1c(C)nnc1-c1ccc(cc1)-c1ccccc1 |(46.21,-23.09,;44.88,-22.32,;43.54,-23.09,;43.55,-24.63,;42.21,-25.4,;40.88,-24.63,;40.88,-23.09,;42.22,-22.33,;42.22,-20.79,;43.46,-19.89,;44.93,-20.37,;42.99,-18.42,;41.45,-18.42,;40.97,-19.89,;39.65,-20.66,;39.65,-22.21,;38.32,-22.98,;36.99,-22.21,;36.98,-20.68,;38.3,-19.9,;35.66,-22.98,;34.33,-22.22,;33,-22.99,;33,-24.54,;34.33,-25.31,;35.67,-24.53,)|
Structure:
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