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Target
Cell division protein FtsZ
Ligand
BDBM50335238
Substrate
n/a
Meas. Tech.
ChEMBL_702652 (CHEMBL1657588)
IC50
6210±n/a nM
Citation
 Kumar, K; Awasthi, D; Lee, SY; Zanardi, I; Ruzsicska, B; Knudson, S; Tonge, PJ; Slayden, RA; Ojima, I Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem 54:374-81 (2011) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_MYCTU | ftsZ
Type:
PROTEIN
Mol. Mass.:
38736.30
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1470459
Residue:
379
Sequence:
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR
  
Inhibitor
Name:
BDBM50335238
Synonyms:
5-Benzamido-2-cyclohexyl-6-N,N-diethylamino-1H-benzo-[d]imidazole | CHEMBL1651196
Type:
Small organic molecule
Emp. Form.:
C24H30N4O
Mol. Mass.:
390.5212
SMILES:
CCN(CC)c1cc2[nH]c(nc2cc1NC(=O)c1ccccc1)C1CCCCC1
Structure:
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