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Target
Translocator protein
Ligand
BDBM50335259
Substrate
n/a
Meas. Tech.
ChEMBL_702766 (CHEMBL1655209)
Ki
0.3±n/a nM
Citation
 Pike, VW; Taliani, S; Lohith, TG; Owen, DR; Pugliesi, I; Da Pozzo, E; Hong, J; Zoghbi, SS; Gunn, RN; Parker, CA; Rabiner, EA; Fujita, M; Innis, RB; Martini, C; Da Settimo, F Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J Med Chem 54:366-73 (2011) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50335259
Synonyms:
CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-2-oxoacetamide
Type:
Small organic molecule
Emp. Form.:
C25H30N2O2
Mol. Mass.:
390.5179
SMILES:
CCCCN(CCCC)C(=O)C(=O)c1c(-c2ccccc2)n(C)c2ccccc12
Structure:
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