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Target
Cathepsin K
Ligand
BDBM50335280
Substrate
n/a
Meas. Tech.
ChEMBL_702784 (CHEMBL1655227)
Ki
0.011±n/a nM
Citation
 Frizler, M; Lohr, F; Furtmann, N; Kläs, J; Gütschow, M Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors. J Med Chem 54:396-400 (2011) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50335280
Synonyms:
CHEMBL1651354 | N-(Benzylcarbamoyl)-leucyl-methylazaalanine-nitrile | acs.jmedchem.1c00409_ST.408
Type:
Small organic molecule
Emp. Form.:
C17H25N5O2
Mol. Mass.:
331.4127
SMILES:
CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N(C)N(C)C#N |r|
Structure:
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