Reaction Details Report a problem with these data
Target
Steroid hormone receptor ERR1
Ligand
BDBM50336763
Substrate
n/a
Meas. Tech.
ChEMBL_718276 (CHEMBL1679580)
EC50
1000±n/a nM
Citation
 Patch, RJ; Searle, LL; Kim, AJ; De, D; Zhu, X; Askari, HB; O'Neill, JC; Abad, MC; Rentzeperis, D; Liu, J; Kemmerer, M; Lin, L; Kasturi, J; Geisler, JG; Lenhard, JM; Player, MR; Gaul, MD Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. J Med Chem 54:788-808 (2012) [PubMed]  Article 
Target
Name:
Steroid hormone receptor ERR1
Synonyms:
ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
Type:
PROTEIN
Mol. Mass.:
45508.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1499891
Residue:
423
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
  
Inhibitor
Name:
BDBM50336763
Synonyms:
4-(5-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-3-yl)phenol | CHEMBL1671990
Type:
Small organic molecule
Emp. Form.:
C18H18N2O
Mol. Mass.:
278.3483
SMILES:
Cc1ccc(C)c(c1)-c1cc(nn1C)-c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: