Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 2
Ligand
BDBM50336816
Substrate
n/a
Meas. Tech.
ChEMBL_718679 (CHEMBL1680830)
IC50
1600±n/a nM
Citation
 Miyamoto, Y; Banno, Y; Yamashita, T; Fujimoto, T; Oi, S; Moritoh, Y; Asakawa, T; Kataoka, O; Yashiro, H; Takeuchi, K; Suzuki, N; Ikedo, K; Kosaka, T; Tsubotani, S; Tani, A; Sasaki, M; Funami, M; Amano, M; Yamamoto, Y; Aertgeerts, K; Yano, J; Maezaki, H Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. J Med Chem 54:831-50 (2012) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DPP2_RAT | Dipeptidyl peptidase II | Dpp2 | Dpp7
Type:
PROTEIN
Mol. Mass.:
55100.60
Organism:
Rattus norvegicus
Description:
ChEMBL_718679
Residue:
500
Sequence:
MGLHPCSPVDHGVPSWVLVLLLTLGLCSLQATADSVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSLANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRHNLGVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTNFLGPLPANPVKVGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSCADPTGCGTGSNARAWDYQACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRPDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLEATLIREWVAAARLKQPAEAQWPGPK
  
Inhibitor
Name:
BDBM50336816
Synonyms:
5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methylethyl)-4-(4-methylphenyl)pyridine-3-carboxylicAcid Dihydrochloride | CHEMBL1672123
Type:
Small organic molecule
Emp. Form.:
C22H30N2O2
Mol. Mass.:
354.4858
SMILES:
CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: